منابع مشابه
The molecular crosstalk: oxidative stress, genomic instability and neurodegenerative disorders
Genomic stability is a commitment of regulation and establishment of cell lines in organisms. The instability of genomes greatly affects maintenance of genetic profile and is directly or indirectly associated with many disorders. With the exception of cancer, genomic instability is widely associated with neurodegenerative disorders. The conflicts among the molecular mechanisms, such as replicat...
متن کاملGenomic instability
in the popular tale " Ozma of Oz, " Lyman Frank Baum describes the princess Langwidere, who is capable of interchanging her currently worn head with another one, using a collection of heads stored in a cabinet. Remarkably, she changes her character as well when putting a new head on her neck. in the December 15, 2012 issue of Cell Cycle, Kurt Engeland and colleagues report a similar phenomenon ...
متن کاملgenomic and epigenetic instability in colorectal cancer
abstract: colorectal cancer (crc) is the third most common cancer in men and the second most common cancer in women worldwide. both genetic and epigenetic alterations are common in crc and are the driving force of tumorigenesis. chromosomal instability, microsatellite instability and cpg island methylator phenotype pathways are responsible for genetic instability in colorectal cancer. chromosom...
متن کاملNew questions on genomic instability.
Background: Trauma and surgery may be complicated by pulmonary dysfunction, acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), but the mechanisms are incompletely understood. Methods: We evaluated lung capillary protein permeability non-invasively with help of the 67Gatransferrin pulmonary leak index (PLI) technique and extravascular lung water (EVLW) by the transpulmonary ...
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ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2010
ISSN: 1471-0072,1471-0080
DOI: 10.1038/nrm2842